Mitigating Mutational Meltdown in Mammalian Mitochondria
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چکیده
منابع مشابه
Mitigating Mutational Meltdown in Mammalian Mitochondria
M itochondria are remarkable microorganisms. About two billion years ago, their distant free-living ancestors hooked up with a truly foreign lineage of archaebacteria and started a genomic merger that led to the most successful coevolved mutualism on the planet: the eukaryotic cell. Along the way, evolving mitochondria lost a lot of genomic baggage, entrusted their emerging hosts with their own...
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In small or repeatedly bottlenecked populations, mutations are expected to accumulate by genetic drift, causing fitness declines. In mutational meltdown models, such fitness declines further reduce population size, thus accelerating additional mutation accumulation and leading to extinction. Because the rate of mutation accumulation is determined partly by the mutation rate, the risk and rate o...
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When a new mdividual is formed (independently of the reproduction process) it inherits harmful iuutations. Moreover, new mutations are acquired even in the genetic code formation, most of them deleterious ones. This might lead to a time decay in the mean fitness of the whole population that, for long enough time, ,vould produce the extinction of the
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Loss of fitness due to the accumulation of deleterious mutations appears to be inevitable in small, obligately asexual populations, as these are incapable of reconstituting highly fit genotypes by recombination or back mutation. The cumulative buildup of such mutations is expected to lead to an eventual reduction in population size, and this facilitates the chance accumulation of future mutatio...
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Mutational meltdown, in which demographic and genetic processes mutually reinforce one another to accelerate the extinction of small populations, has been poorly quantified despite its potential importance in conservation biology. Here we present a model-based framework to study and quantify the mutational meltdown in a finite diploid population that is evolving continuously in time and subject...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2008
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.0060035